Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3β/β-catenin signalling pathway

Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3β/β-catenin signalling pathway

Periprosthetic osteolysis (PPO) remains the key factor in implant failure and subsequent revision surgery and is mainly triggered by wear particles. Previous studies have shown that inhibition of osteoblastic differentiation is the most widespread incident affecting the interface of trabecular and l...

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Bibliographic Details
Main Authors: Kai Zheng, Jiaxiang Bai, Ning Li, Meng Li, Houyi Sun, Weicheng Zhang, Gaoran Ge, Xiaolong Liang, Huaqiang Tao, Yi Xue, Yuefeng Hao, Chen Zhu, Yaozeng Xu, Dechun Geng
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2021-10-01
Series:Bioactive Materials
Subjects:
SIRT3
Titanium particles
Periprosthetic osteolysis
NLRP3 inflammasome
Osteoblast
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X21001018

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http://www.sciencedirect.com/science/article/pii/S2452199X21001018

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