Leptin and TGF-β1 Downregulate PREP1 Expression in Human Adipose-Derived Mesenchymal Stem Cells and Mature Adipocytes

Leptin and TGF-β1 Downregulate PREP1 Expression in Human Adipose-Derived Mesenchymal Stem Cells and Mature Adipocytes

Adipose tissue is widely recognized as an extremely active endocrine organ producing adipokines as leptin that bridge metabolism and the immune system. Pre-B-cell leukemia homeobox (Pbx)-regulating protein-1 (PREP1) is a ubiquitous homeodomain transcription factor involved in the adipogenic differen...

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Bibliographic Details
Main Authors: Andreina Bruno, Caterina Di Sano, Hans-Uwe Simon, Pascal Chanez, Angelo Maria Patti, Serena Di Vincenzo, Paola Dino, Vittoria D’Esposito, Pietro Formisano, Francesco Beguinot, Elisabetta Pace
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
adipose tissue
adipocytes
adipocyte-derived stem cells
leptin
PREP1
TLR4
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.700481/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.700481/full

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