ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield

ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield

The mechanisms underlying differential chemotherapeutic response to 5-fluorouracil are not fully known. Here, the authors show that ABDH5 regulates sensitivity to 5-fluorouracil in colorectal cancer by regulating lysosome function.

Bibliographic Details
Main Authors: Juanjuan Ou, Yuan Peng, Weiwen Yang, Yue Zhang, Jie Hao, Fu Li, Yanrong Chen, Yang Zhao, Xiong Xie, Shuang Wu, Lin Zha, Xi Luo, Ganfeng Xie, Liting Wang, Wei Sun, Qi Zhou, Jianjun Li, Houjie Liang
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08902-x

Internet

https://doi.org/10.1038/s41467-019-08902-x

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