Derangements of amino acids in cachectic skeletal muscle are caused by mitochondrial dysfunction

Derangements of amino acids in cachectic skeletal muscle are caused by mitochondrial dysfunction

Abstract Background Cachexia is the direct cause of at least 20% of cancer‐associated deaths. Muscle wasting in skeletal muscle results in weakness, immobility, and death secondary to impaired respiratory muscle function. Muscle proteins are massively degraded in cachexia; nevertheless, the molecula...

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Bibliographic Details
Main Authors: Thomas Kunzke, Achim Buck, Verena M. Prade, Annette Feuchtinger, Olga Prokopchuk, Marc E. Martignoni, Simone Heisz, Hans Hauner, Klaus‐Peter Janssen, Axel Walch, Michaela Aichler
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Cancer cachexia
Mitochondrial dysfunctions
Amino acids
MALDI
Mass spectrometry imaging
Online Access:https://doi.org/10.1002/jcsm.12498

Internet

https://doi.org/10.1002/jcsm.12498

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