Synthesis and In Vitro AMPK Activation of Cycloalkyl/Alkarylbiguanides with Robust In Vivo Antihyperglycemic Action

Synthesis and In Vitro AMPK Activation of Cycloalkyl/Alkarylbiguanides with Robust In Vivo Antihyperglycemic Action

This work describes the design, synthesis in one step, and the in vitro, in vivo, and in silico antidiabetic evaluation of a series of ten alicyclic and aromatic (alkyl +aryl: alkaryl)biguanides, analogues of metformin and phenformin. The design was conceived using isosteric replacement, chain-ring...

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Bibliographic Details
Main Authors: Erika Gutierrez-Lara, Carlos Martínez-Conde, Edgar Rosales-Ortega, Juan José Ramírez-Espinosa, Julio C. Rivera-Leyva, David Centurión, Karla Carvajal, Daniel Ortega-Cuellar, Samuel Estrada-Soto, Gabriel Navarrete-Vázquez
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2017/1212609

Internet

http://dx.doi.org/10.1155/2017/1212609

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