Secretion of bispecific protein of anti-PD-1 fused with TGF-β trap enhances antitumor efficacy of CAR-T cell therapy

Secretion of bispecific protein of anti-PD-1 fused with TGF-β trap enhances antitumor efficacy of CAR-T cell therapy

Despite the remarkable success of chimeric antigen receptor-modified T (CAR-T) cell therapy for blood malignancies, the clinical efficacy of this novel therapy in solid tumor treatment is largely limited by the immunosuppressive tumor microenvironment (TME). For instance, immune checkpoints (e.g., p...

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Bibliographic Details
Main Authors: Xianhui Chen, Shuai Yang, Si Li, Yun Qu, Hsuan-Yao Wang, Jiangyue Liu, Zachary S. Dunn, Gunce E. Cinay, Melanie A. MacMullan, Fangheng Hu, Xiaoyang Zhang, Pin Wang
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
chimeric antigen receptor
tumor growth factor beta
immune checkpoint
PD-1
PD-L1
tumor microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521000486

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http://www.sciencedirect.com/science/article/pii/S2372770521000486

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