Mucosal delivery of Lactococcus lactis carrying an anti-TNF scFv expression vector ameliorates experimental colitis in mice

Mucosal delivery of Lactococcus lactis carrying an anti-TNF scFv expression vector ameliorates experimental colitis in mice

Abstract Background Anti-Tumor Necrosis Factor-alpha therapy has become clinically important for treating inflammatory bowel disease. However, the use of conventional immunotherapy requires a systemic exposure of patients and collateral side effects. Lactic acid bacteria have been shown to be effect...

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Bibliographic Details
Main Authors: Maria José Chiabai, Juliana Franco Almeida, Mariana Gabriela Dantas de Azevedo, Suelen Soares Fernandes, Vanessa Bastos Pereira, Raffael Júnio Araújo de Castro, Márcio Sousa Jerônimo, Isabel Garcia Sousa, Leonora Maciel de Souza Vianna, Anderson Miyoshi, Anamelia Lorenzetti Bocca, Andrea Queiroz Maranhão, Marcelo Macedo Brigido
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Biotechnology
Subjects:
Lactococcus lactis
Mucosal delivery
Anti-TNFα
scFv
Colitis
DSS
Online Access:http://link.springer.com/article/10.1186/s12896-019-0518-6

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http://link.springer.com/article/10.1186/s12896-019-0518-6

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