The empirical power of rare variant association methods: results from sanger sequencing in 1,998 individuals.
The role of rare genetic variation in the etiology of complex disease remains unclear. However, the development of next-generation sequencing technologies offers the experimental opportunity to address this question. Several novel statistical methodologies have been recently proposed to assess the c...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-02-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC3271058?pdf=render |