RANBP2 Activates <i>O</i>-GlcNAcylation through Inducing CEBPα-Dependent OGA Downregulation to Promote Hepatocellular Carcinoma Malignant Phenotypes

RANBP2 Activates <i>O</i>-GlcNAcylation through Inducing CEBPα-Dependent OGA Downregulation to Promote Hepatocellular Carcinoma Malignant Phenotypes

<i>O</i>-GlcNAcylation is an important post-translational modification (PTM) jointly controlled by <i>O</i>-GlcNAc transferase (OGT) and <i>O</i>-GlcNAcase (OGA). Aberrant hyper-<i>O</i>-GlcNAcylation is reported to yield hepatocellular carcinoma (HCC)...

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Bibliographic Details
Main Authors: Xiaoming Liu, Xingyu Chen, Mengqing Xiao, Yuxing Zhu, Renjie Gong, Jianye Liu, Qinghai Zeng, Canxia Xu, Xiong Chen, Fen Wang, Ke Cao
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
RANBP2
SUMOylation
<i>O</i>-GlcNAcylation
CEBPα
OGA
hepatocellular carcinoma
Online Access:https://www.mdpi.com/2072-6694/13/14/3475

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https://www.mdpi.com/2072-6694/13/14/3475

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