Mapping network motif tunability and robustness in the design of synthetic signaling circuits.

Cellular networks are highly dynamic in their function, yet evolutionarily conserved in their core network motifs or topologies. Understanding functional tunability and robustness of network motifs to small perturbations in function and structure is vital to our ability to synthesize controllable ci...

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Bibliographic Details
Main Authors: Sergio Iadevaia, Luay K Nakhleh, Robert Azencott, Prahlad T Ram
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3958390?pdf=render