A Point Mutation in p190A RhoGAP Affects Ciliogenesis and Leads to Glomerulocystic Kidney Defects.

A Point Mutation in p190A RhoGAP Affects Ciliogenesis and Leads to Glomerulocystic Kidney Defects.

Rho family GTPases act as molecular switches regulating actin cytoskeleton dynamics. Attenuation of their signaling capacity is provided by GTPase-activating proteins (GAPs), including p190A, that promote the intrinsic GTPase activity of Rho proteins. In the current study we have performed a small-s...

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Bibliographic Details
Main Authors: Katherine Stewart, Yaned Gaitan, Maxwell E R Shafer, Lamine Aoudjit, Di Hu, Richa Sharma, Mathieu Tremblay, Hidetaka Ishii, Michael Marcotte, Daniela Stanga, You Chi Tang, Sami Kamel Boualia, Alana H T Nguyen, Tomoko Takano, Nathalie Lamarche-Vane, Silvia Vidal, Maxime Bouchard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4747337?pdf=render

Internet

http://europepmc.org/articles/PMC4747337?pdf=render

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