Impairment of Motor Function Correlates with Neurometabolite and Brain Iron Alterations in Parkinson’s Disease

Impairment of Motor Function Correlates with Neurometabolite and Brain Iron Alterations in Parkinson’s Disease

We took advantage of magnetic resonance imaging (MRI) and spectroscopy (MRS) as non-invasive methods to quantify brain iron and neurometabolites, which were analyzed along with other predictors of motor dysfunction in Parkinson’s disease (PD). Tapping hits, tremor amplitude, and the scores derived f...

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Bibliographic Details
Main Authors: Beate Pesch, Swaantje Casjens, Dirk Woitalla, Shalmali Dharmadhikari, David A. Edmondson, Maria Angela Samis Zella, Martin Lehnert, Anne Lotz, Lennard Herrmann, Siegfried Muhlack, Peter Kraus, Chien-Lin Yeh, Benjamin Glaubitz, Tobias Schmidt-Wilcke, Ralf Gold, Christoph van Thriel, Thomas Brüning, Lars Tönges, Ulrike Dydak
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cells
Subjects:
Parkinson’s disease
brain iron
motor dysfunction
neurometabolites
magnetic resonance imaging
magnetic resonance spectroscopy
GABA
spectroscopy
Online Access:https://www.mdpi.com/2073-4409/8/2/96

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https://www.mdpi.com/2073-4409/8/2/96

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