Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure

Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure

PKD2 (polycystin-2, TRPP1), a TRP polycystin channel, is expressed in endothelial cells (ECs), but its physiological functions in this cell type are unclear. Here, we generated inducible, EC-specific Pkd2 knockout mice to examine vascular functions of PKD2. Data show that a broad range of intravascu...

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Bibliographic Details
Main Authors: Charles E MacKay, M Dennis Leo, Carlos Fernández-Peña, Raquibul Hasan, Wen Yin, Alejandro Mata-Daboin, Simon Bulley, Jesse Gammons, Salvatore Mancarella, Jonathan H Jaggar
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
flow mediated-vasodilation
polycystin-2
blood pressure
endothelial cell
Online Access:https://elifesciences.org/articles/56655

Internet

https://elifesciences.org/articles/56655

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