Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity

Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity

Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction pathways that regulate all aspects of life and are frequently altered in disease. Here, we focus on the role of MAPK pathways in modulating drug sensitivity and resistance in cancer. We briefly discuss new find...

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Bibliographic Details
Main Authors: Shannon Lee, Jens Rauch, Walter Kolch
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
mapk
erk
jnk
p38
cancer
drug resistance
combination therapy
metabolism
epigenetics
Online Access:https://www.mdpi.com/1422-0067/21/3/1102

Internet

https://www.mdpi.com/1422-0067/21/3/1102

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