Chemical Variations on the p53 Reactivation Theme

Chemical Variations on the p53 Reactivation Theme

Among the tumor suppressor genes, p53 is one of the most studied. It is widely regarded as the “guardian of the genome”, playing a major role in carcinogenesis. In fact, direct inactivation of the TP53 gene occurs in more than 50% of malignancies, and in tumors that retain wild-type p53 status, its...

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Bibliographic Details
Main Authors: Carlos J. A. Ribeiro, Cecília M. P. Rodrigues, Rui Moreira, Maria M. M. Santos
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Pharmaceuticals
Subjects:
small molecules
MDM2 inhibitors
MDMX inhibitors
p53 activators
p53-MDM2 interaction inhibitors
p53-MDMX interaction inhibitors
mutant p53
wild-type p53
Online Access:http://www.mdpi.com/1424-8247/9/2/25

Internet

http://www.mdpi.com/1424-8247/9/2/25

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