Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network

Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network

Objective: Mice lacking the bHLH transcription factor (TF) Neurog3 do not form pancreatic islet cells, including insulin-secreting beta cells, the absence of which leads to diabetes. In humans, homozygous mutations of NEUROG3 manifest with neonatal or childhood diabetes. Despite this critical role i...

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Bibliographic Details
Main Authors: Valérie Schreiber, Reuben Mercier, Sara Jiménez, Tao Ye, Emmanuel García-Sánchez, Annabelle Klein, Aline Meunier, Sabitri Ghimire, Catherine Birck, Bernard Jost, Kristian Honnens de Lichtenberg, Christian Honoré, Palle Serup, Gérard Gradwohl
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Molecular Metabolism
Subjects:
NEUROG3
iPSC
Islet progenitors
CUT&RUN
T2DM
SNPs
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821001605

Internet

http://www.sciencedirect.com/science/article/pii/S2212877821001605

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