The pursuit of balance in sequential randomized trials

In many randomized trials, subjects enter the sample sequentially. Because the covariates for all units are not known in advance, standard methods of stratification do not apply. We describe and assess the method of DA-optimal sequential allocation (Atkinson, 1982) for balancing stratification covar...

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Bibliographic Details
Main Authors: Raymond P. Guiteras, David I. Levine, Thomas H. Polley
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Development Engineering
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2352728515300580