Limited Proteolysis of Cyclooxygenase-2 Enhances Cell Proliferation

Limited Proteolysis of Cyclooxygenase-2 Enhances Cell Proliferation

Accumulating evidence suggests that the cyclooxygenase-2 (COX-2) enzyme has additional catalytic-independent functions. Here we show that COX-2 appears to be cleaved in mouse and human tumors, which led us to hypothesize that COX-2 proteolysis may play a role in cell proliferation. The data presente...

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Bibliographic Details
Main Authors: Esraa Saadi, Rapita Sood, Ido Dromi, Ranin Srouji, Ossama Abu Hatoum, Sharon Tal, Liza Barki-Harrington
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
Cyclooxygenase-2 (COX-2)
proteolysis
proliferation
β-catenin
cleavage
Online Access:https://www.mdpi.com/1422-0067/21/9/3195

Internet

https://www.mdpi.com/1422-0067/21/9/3195

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