Limited Proteolysis of Cyclooxygenase-2 Enhances Cell Proliferation
Accumulating evidence suggests that the cyclooxygenase-2 (COX-2) enzyme has additional catalytic-independent functions. Here we show that COX-2 appears to be cleaved in mouse and human tumors, which led us to hypothesize that COX-2 proteolysis may play a role in cell proliferation. The data presente...
Main Authors: | Esraa Saadi, Rapita Sood, Ido Dromi, Ranin Srouji, Ossama Abu Hatoum, Sharon Tal, Liza Barki-Harrington |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-04-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/21/9/3195 |
Similar Items
-
Significance of cyclooxygenase-2 in oncogenesis
by: Szweda Marta, et al.
Published: (2019-06-01) -
Molecular docking study of active phytocompounds from the methanolic leaf extract of vitex negundo against cyclooxygenase-2
by: Deepa Murugesan, et al.
Published: (2014-03-01) -
Cyclooxygenase-1 (COX-1) and COX-1 Inhibitors in Cancer: A Review of Oncology and Medicinal Chemistry Literature
by: Alessandra Pannunzio, et al.
Published: (2018-10-01) -
Cyclooxygenase-2 identified as a potential target for novel radiomodulator scopolamine methyl bromide: An in silico study
by: Nitisha Shrivastava, et al.
Published: (2017-01-01) -
OPTIMIZING STRUCTURE-BASED VIRTUAL SCREENING PROTOCOL TO IDENTIFY PHYTOCHEMICALS AS CYCLOOXYGENASE-2 INHIBITORS
by: Enade Perdana Istyastono
Published: (2016-07-01)