Co-expression of SERCA isoforms, phospholamban and sarcolipin in human skeletal muscle fibers.

Co-expression of SERCA isoforms, phospholamban and sarcolipin in human skeletal muscle fibers.

Sarcolipin (SLN) and phospholamban (PLN) inhibit the activity of sarco(endo)plasmic reticulum Ca(2+)-ATPases (SERCAs) by reducing their apparent affinity for Ca(2+). A ternary complex between SLN, PLN, and SERCAs results in super-inhibition of SERCA activity. Analysis of skeletal muscle homogenate h...

Full description

Bibliographic Details
Main Authors: Val A Fajardo, Eric Bombardier, Chris Vigna, Tahira Devji, Darin Bloemberg, Daniel Gamu, Anthony O Gramolini, Joe Quadrilatero, A Russell Tupling
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3865254?pdf=render

Internet

http://europepmc.org/articles/PMC3865254?pdf=render

Similar Items