Co-expression of SERCA isoforms, phospholamban and sarcolipin in human skeletal muscle fibers.
Sarcolipin (SLN) and phospholamban (PLN) inhibit the activity of sarco(endo)plasmic reticulum Ca(2+)-ATPases (SERCAs) by reducing their apparent affinity for Ca(2+). A ternary complex between SLN, PLN, and SERCAs results in super-inhibition of SERCA activity. Analysis of skeletal muscle homogenate h...
Main Authors: | Val A Fajardo, Eric Bombardier, Chris Vigna, Tahira Devji, Darin Bloemberg, Daniel Gamu, Anthony O Gramolini, Joe Quadrilatero, A Russell Tupling |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3865254?pdf=render |
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