Neurotrophin-3 Promotes Cell Death Induced in Cerebral Ischemia, Oxygen-Glucose Deprivation, and Oxidative Stress: Possible Involvement of Oxygen Free Radicals

Neurotrophin-3 Promotes Cell Death Induced in Cerebral Ischemia, Oxygen-Glucose Deprivation, and Oxidative Stress: Possible Involvement of Oxygen Free Radicals

To explore the role of neurotrophin-3 (NT-3) during cerebral ischemia, NT-3-deficient brains were subjected to transient focal ischemia. Conditional mutant brains produced undetectable amounts of NT-3 mRNA, whereas the expression of the neurotrophin, BDNF, the NT-3 receptor, TrkC, and the nonselecti...

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Bibliographic Details
Main Authors: Brian Bates, Lorenz Hirt, Sunu S. Thomas, Schahram Akbarian, Dean Le, Sepideh Amin-Hanjani, Michael Whalen, Rudolf Jaenisch, Michael A. Moskowitz
Format: Article
Language:English
Published: Elsevier 2002-02-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996101904589

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http://www.sciencedirect.com/science/article/pii/S0969996101904589

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