Kaempferol Inhibits Zearalenone-Induced Oxidative Stress and Apoptosis via the PI3K/Akt-Mediated Nrf2 Signaling Pathway: In Vitro and In Vivo Studies

Kaempferol Inhibits Zearalenone-Induced Oxidative Stress and Apoptosis via the PI3K/Akt-Mediated Nrf2 Signaling Pathway: In Vitro and In Vivo Studies

In this study, kaempferol (KFL) shows hepatoprotective activity against zearalenone (ZEA)-induced oxidative stress and its underlying mechanisms in in vitro and in vivo models were investigated. Oxidative stress plays a critical role in the pathophysiology of various hepatic ailments and is normally...

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Bibliographic Details
Main Authors: Peramaiyan Rajendran, Rebai Ben Ammar, Fatma J. Al-Saeedi, Maged E. Mohamed, Medhat A. ElNaggar, Saeed Y. Al-Ramadan, Gamal M. Bekhet, Ahmed M. Soliman
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
zearalenone
kaempferol
PI3K/Akt
hepatotoxicity
Nrf2
apoptosis
Online Access:https://www.mdpi.com/1422-0067/22/1/217

Internet

https://www.mdpi.com/1422-0067/22/1/217

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