Matrix Metalloproteinase 13 Genotype in rs640198 Polymorphism Is Associated with Severe Coronary Artery Disease

Atherosclerosis as a main etiopathogenetic source for coronary artery disease (CAD) development is intimately related to dynamic changes in the extracellular matrix (ECM). Elevated levels of MMP-13 have been observed in human atherosclerotic plaques which could also involve variability in MMP-13 gen...

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Main Authors: Anna Vašků, Jaroslav Meluzín, Jan Blahák, Vladimír Kincl, Monika Pávková Goldbergová, Jan Sitar, Filip Zlámal, Julie Bienertová-Vašků, Jiří Vítovec
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.3233/DMA-2012-0902