Matrix Metalloproteinase 13 Genotype in rs640198 Polymorphism Is Associated with Severe Coronary Artery Disease

Matrix Metalloproteinase 13 Genotype in rs640198 Polymorphism Is Associated with Severe Coronary Artery Disease

Atherosclerosis as a main etiopathogenetic source for coronary artery disease (CAD) development is intimately related to dynamic changes in the extracellular matrix (ECM). Elevated levels of MMP-13 have been observed in human atherosclerotic plaques which could also involve variability in MMP-13 gen...

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Main Authors: Anna Vašků, Jaroslav Meluzín, Jan Blahák, Vladimír Kincl, Monika Pávková Goldbergová, Jan Sitar, Filip Zlámal, Julie Bienertová-Vašků, Jiří Vítovec
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.3233/DMA-2012-0902
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spelling doaj-0f02c2064d564803b78c0b46d8cb7cb42020-11-25T00:14:23ZengHindawi LimitedDisease Markers0278-02401875-86302012-01-01331434910.3233/DMA-2012-0902Matrix Metalloproteinase 13 Genotype in rs640198 Polymorphism Is Associated with Severe Coronary Artery DiseaseAnna Vašků0Jaroslav Meluzín1Jan Blahák2Vladimír Kincl3Monika Pávková Goldbergová4Jan Sitar5Filip Zlámal6Julie Bienertová-Vašků7Jiří Vítovec8Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic1st. Department of Internal Medicine/Cardioangiology, ICRC, St. Anna Hospital, Masaryk University, Brno, Czech RepublicDepartment of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic1st. Department of Internal Medicine/Cardioangiology, ICRC, St. Anna Hospital, Masaryk University, Brno, Czech RepublicDepartment of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic1st. Department of Internal Medicine/Cardioangiology, ICRC, St. Anna Hospital, Masaryk University, Brno, Czech RepublicDepartment of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech RepublicDepartment of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic1st. Department of Internal Medicine/Cardioangiology, ICRC, St. Anna Hospital, Masaryk University, Brno, Czech RepublicAtherosclerosis as a main etiopathogenetic source for coronary artery disease (CAD) development is intimately related to dynamic changes in the extracellular matrix (ECM). Elevated levels of MMP-13 have been observed in human atherosclerotic plaques which could also involve variability in MMP-13 gene. The aim of the study was to associate rs640198 polymorphism with CAD and/or with its severity.http://dx.doi.org/10.3233/DMA-2012-0902
collection DOAJ
language English
format Article
sources DOAJ
author Anna Vašků
Jaroslav Meluzín
Jan Blahák
Vladimír Kincl
Monika Pávková Goldbergová
Jan Sitar
Filip Zlámal
Julie Bienertová-Vašků
Jiří Vítovec
spellingShingle Anna Vašků
Jaroslav Meluzín
Jan Blahák
Vladimír Kincl
Monika Pávková Goldbergová
Jan Sitar
Filip Zlámal
Julie Bienertová-Vašků
Jiří Vítovec
Matrix Metalloproteinase 13 Genotype in rs640198 Polymorphism Is Associated with Severe Coronary Artery Disease
Disease Markers
author_facet Anna Vašků
Jaroslav Meluzín
Jan Blahák
Vladimír Kincl
Monika Pávková Goldbergová
Jan Sitar
Filip Zlámal
Julie Bienertová-Vašků
Jiří Vítovec
author_sort Anna Vašků
title Matrix Metalloproteinase 13 Genotype in rs640198 Polymorphism Is Associated with Severe Coronary Artery Disease
title_short Matrix Metalloproteinase 13 Genotype in rs640198 Polymorphism Is Associated with Severe Coronary Artery Disease
title_full Matrix Metalloproteinase 13 Genotype in rs640198 Polymorphism Is Associated with Severe Coronary Artery Disease
title_fullStr Matrix Metalloproteinase 13 Genotype in rs640198 Polymorphism Is Associated with Severe Coronary Artery Disease
title_full_unstemmed Matrix Metalloproteinase 13 Genotype in rs640198 Polymorphism Is Associated with Severe Coronary Artery Disease
title_sort matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease
publisher Hindawi Limited
series Disease Markers
issn 0278-0240
1875-8630
publishDate 2012-01-01
description Atherosclerosis as a main etiopathogenetic source for coronary artery disease (CAD) development is intimately related to dynamic changes in the extracellular matrix (ECM). Elevated levels of MMP-13 have been observed in human atherosclerotic plaques which could also involve variability in MMP-13 gene. The aim of the study was to associate rs640198 polymorphism with CAD and/or with its severity.
url http://dx.doi.org/10.3233/DMA-2012-0902
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