NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells

NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells

Objective: The glucose stimulation of insulin secretion (GSIS) by pancreatic β-cells critically depends on increased production of metabolic coupling factors, including NADPH. Nicotinamide nucleotide transhydrogenase (NNT) typically produces NADPH at the expense of NADH and ΔpH in energized mitochon...

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Bibliographic Details
Main Authors: Laila R.B. Santos, Carole Muller, Arnaldo H. de Souza, Hilton K. Takahashi, Peter Spégel, Ian R. Sweet, Heeyoung Chae, Hindrik Mulder, Jean-Christophe Jonas
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817301424

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http://www.sciencedirect.com/science/article/pii/S2212877817301424

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