Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients

Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients

Abstract Familial Mediterranean fever (FMF) is the most frequent hereditary systemic autoinflammatory syndrome. FMF is usually caused by biallelic mutations in the MEFV gene, encoding Pyrin. Conclusive genetic evidence lacks for about 30% of patients diagnosed with clinical FMF. Pyrin is an inflamma...

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Bibliographic Details
Main Authors: Flora Magnotti, Lucie Lefeuvre, Sarah Benezech, Tiphaine Malsot, Louis Waeckel, Amandine Martin, Sébastien Kerever, Daria Chirita, Marine Desjonqueres, Agnès Duquesne, Mathieu Gerfaud‐Valentin, Audrey Laurent, Pascal Sève, Michel‐Robert Popoff, Thierry Walzer, Alexandre Belot, Yvan Jamilloux, Thomas Henry
Format: Article
Language:English
Published: Wiley 2019-11-01
Series:EMBO Molecular Medicine
Subjects:
autoinflammation
caspase‐1
colchicine
diagnosis
pyroptosis
Online Access:https://doi.org/10.15252/emmm.201910547

Internet

https://doi.org/10.15252/emmm.201910547

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