Capsaicin Analogues Derived from <i>n</i>-3 Polyunsaturated Fatty Acids (PUFAs) Reduce Inflammatory Activity of Macrophages and Stimulate Insulin Secretion by β-Cells In Vitro

Capsaicin Analogues Derived from <i>n</i>-3 Polyunsaturated Fatty Acids (PUFAs) Reduce Inflammatory Activity of Macrophages and Stimulate Insulin Secretion by β-Cells In Vitro

In this study, two capsaicin analogues, <i>N</i>-eicosapentaenoyl vanillylamine (EPVA) and <i>N</i>-docosahexaenoyl vanillylamine (DHVA), were enzymatically synthesized from their corresponding <i>n</i>-3 long chain polyunsaturated fatty acids eicosapentaenoic aci...

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Bibliographic Details
Main Authors: Erika Cione, Pierluigi Plastina, Attilio Pingitore, Mariarita Perri, Maria Cristina Caroleo, Alessia Fazio, Renger Witkamp, Jocelijn Meijerink
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Nutrients
Subjects:
diabetes
fatty acid amides
inflammation
obesity
PUFA
vanillylamide
Online Access:https://www.mdpi.com/2072-6643/11/4/915

Internet

https://www.mdpi.com/2072-6643/11/4/915

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