Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences.

Mesolimbic dopamine (DA) is involved in behavioral activation and effort-related processes. Rats with impaired DA transmission reallocate their instrumental behavior away from food-reinforced tasks with high response requirements, and instead select less effortful food-seeking behaviors. In the pres...

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Bibliographic Details
Main Authors: Patrick A Randall, Marta Pardo, Eric J Nunes, Laura López Cruz, V Kiran Vemuri, Alex Makriyannis, Younis Baqi, Christa E Müller, Mercè Correa, John D Salamone
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3478264?pdf=render