Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification

Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification

Protozoan parasites of the genus Leishmania cause severe human and veterinary diseases worldwide, termed leishmaniases. A hallmark of Leishmania biology is its capacity to adapt to a variety of unpredictable fluctuations inside its human host, notably pharmacological interventions, thus, causing dru...

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Bibliographic Details
Main Authors: Giovanni Bussotti, Evi Gouzelou, Mariana Côrtes Boité, Ihcen Kherachi, Zoubir Harrat, Naouel Eddaikra, Jeremy C. Mottram, Maria Antoniou, Vasiliki Christodoulou, Aymen Bali, Fatma Z. Guerfali, Dhafer Laouini, Maowia Mukhtar, Franck Dumetz, Jean-Claude Dujardin, Despina Smirlis, Pierre Lechat, Pascale Pescher, Adil El Hamouchi, Meryem Lemrani, Carmen Chicharro, Ivonne Pamela Llanes-Acevedo, Laura Botana, Israel Cruz, Javier Moreno, Fakhri Jeddi, Karim Aoun, Aïda Bouratbine, Elisa Cupolillo, Gerald F. Späth
Format: Article
Language:English
Published: American Society for Microbiology 2018-11-01
Series:mBio
Subjects:
Leishmania
aneuploidy
evolution
gene copy number variation
genomic adaptation
telomeric amplification
Online Access:https://doi.org/10.1128/mBio.01399-18

Internet

https://doi.org/10.1128/mBio.01399-18

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