Prion Fragment Peptides Are Digested with Membrane Type Matrix Metalloproteinases and Acquire Enzyme Resistance through Cu2+-Binding

Prion Fragment Peptides Are Digested with Membrane Type Matrix Metalloproteinases and Acquire Enzyme Resistance through Cu2+-Binding

Prions are the cause of neurodegenerative disease in humans and other mammals. The structural conversion of the prion protein (PrP) from a normal cellular protein (PrPC) to a protease-resistant isoform (PrPSc) is thought to relate to Cu2+ binding to histidine residues. In this study, we focused on t...

Full description

Bibliographic Details
Main Authors: Aya Kojima, Motomi Konishi, Toshifumi Akizawa
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:Biomolecules
Subjects:
prion protein
fragment peptide
MT1-MMP
MT3-MMP
MMP-7
Cu2+
degradation
Online Access:http://www.mdpi.com/2218-273X/4/2/510

Internet

http://www.mdpi.com/2218-273X/4/2/510

Similar Items