High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

Insulin resistance and other features of the metabolic syndrome are increasingly recognized for their effects on cognitive health. To ascertain mechanisms by which this occurs, we fed mice a very high fat diet (60% kcal by fat) for 17 days or a moderate high fat diet (HFD, 45% kcal by fat) for 8 wee...

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Bibliographic Details
Main Authors: Steven E. Arnold, Irwin Lucki, Bethany R. Brookshire, Gregory C. Carlson, Caroline A. Browne, Hala Kazi, Sookhee Bang, Bo-Ran Choi, Yong Chen, Mary F. McMullen, Sangwon F. Kim
Format: Article
Language:English
Published: Elsevier 2014-07-01
Series:Neurobiology of Disease
Subjects:
Insulin
Insulin receptor substrate 1
Akt
GSK3
mTOR
IPMK
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000722

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http://www.sciencedirect.com/science/article/pii/S0969996114000722

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