Pharmacological Profile for the Contribution of NO/cGMP Pathway on Chlorpheniramine Antidepressant-Like Effect in Mice Forced Swim Test

Pharmacological Profile for the Contribution of NO/cGMP Pathway on Chlorpheniramine Antidepressant-Like Effect in Mice Forced Swim Test

Chlorpheniramine, a first-generation antihistamine, is widely used for allergic reactions. Previous studies showed the interaction between antidepressant activity and nitric oxide and cyclic guanosine monophosphate (NO/cGMP) pathway. Thus, we aimed to assess the possible involvement of NO/cGMP path...

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Bibliographic Details
Main Authors: Saeed Shakiba, Nazanin Rajai, Mehdi Qaempanah, Nazgol‐Sadat Haddadi, Abbas Norouzi-Javidan, Reyhaneh Akbarian, Sattar Ostadhadi, Ahmad-Reza Dehpour
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2018-11-01
Series:Acta Medica Iranica
Subjects:
Chlorpheniramine
Nitric oxide
Cyclic guanosine monophosphate
Forced swim test
Mice
Online Access:https://acta.tums.ac.ir/index.php/acta/article/view/6933

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https://acta.tums.ac.ir/index.php/acta/article/view/6933

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