Long non-coding RNA MALAT1 enhances the apoptosis of cardiomyocytes through autophagy inhibition by regulating TSC2-mTOR signaling

Long non-coding RNA MALAT1 enhances the apoptosis of cardiomyocytes through autophagy inhibition by regulating TSC2-mTOR signaling

Abstract Background Our previous study showed that knockdown of long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) attenuated myocardial apoptosis in mouse acute myocardial infarction (AMI). This study aims to explore whether MALAT1 enhanced cardiomyocyte apo...

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Bibliographic Details
Main Authors: Hao Hu, Jiawei Wu, Xiaofan Yu, Junling Zhou, Hua Yu, Likun Ma
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Biological Research
Subjects:
MALAT1
Cardiomyocyte apoptosis
Autophagy
TSC2-mTOR
EZH2
Online Access:https://doi.org/10.1186/s40659-019-0265-0

Internet

https://doi.org/10.1186/s40659-019-0265-0

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