17α-Ethynyl-5α-androstane-3α, 17β-diol Treatment of MNU-Induced Mammary Cancer in Rats

N-methyl-N-nitrosourea (MNU) induces estrogen-dependent mammary tumors in female Lewis rats. We explored the antineoplastic activity of a synthetic androstane derivative, 17α-ethynyl-5α-androstane-3α, 17β-diol (HE3235), as a single agent or in combination with docetaxel compared to tamoxifen, anast...

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Bibliographic Details
Main Authors: Clarence N. Ahlem, James M. Frincke, Steven K. White, Christopher L. Reading, Richard J. Trauger, Rajkumar Lakshmanaswamy
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:International Journal of Breast Cancer
Online Access:http://dx.doi.org/10.4061/2011/618757