Biodegradable Tri-Block Copolymer Poly(lactic acid)-poly(ethylene glycol)-poly(L-lysine)(PLA-PEG-PLL) as a Non-Viral Vector to Enhance Gene Transfection

Biodegradable Tri-Block Copolymer Poly(lactic acid)-poly(ethylene glycol)-poly(L-lysine)(PLA-PEG-PLL) as a Non-Viral Vector to Enhance Gene Transfection

Low cytotoxicity and high gene transfection efficiency are critical issues in designing current non-viral gene delivery vectors. The purpose of the present work was to synthesize the novel biodegradable poly (lactic acid)-poly(ethylene glycol)-poly(L-lysine) (PLA-PEG-PLL) copolymer, and explore its...

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Bibliographic Details
Main Authors: Na Zhang, Chunhua Fu, Xiaoli Sun, Donghua Liu, Zaijun Lu, Zhijing Chen
Format: Article
Language:English
Published: MDPI AG 2011-02-01
Series:International Journal of Molecular Sciences
Subjects:
PLA-PEG-PLL
nanoparticles
non-viral gene vector
gene transfection
tri-block copolymer
Online Access:http://www.mdpi.com/1422-0067/12/2/1371/

Internet

http://www.mdpi.com/1422-0067/12/2/1371/

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