Antiviral Innate Immune Response Interferes with the Formation of Replication-Associated Membrane Structures Induced by a Positive-Strand RNA Virus

Infection with nidoviruses like corona- and arteriviruses induces a reticulovesicular network of interconnected endoplasmic reticulum (ER)-derived double-membrane vesicles (DMVs) and other membrane structures. This network is thought to accommodate the viral replication machinery and protect it from...

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Bibliographic Details
Main Authors: Diede Oudshoorn, Barbara van der Hoeven, Ronald W. A. L. Limpens, Corrine Beugeling, Eric J. Snijder, Montserrat Bárcena, Marjolein Kikkert
Format: Article
Language:English
Published: American Society for Microbiology 2016-12-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/7/6/e01991-16