A new perspective of triptolide-associated hepatotoxicity: the relevance of NF-κB and NF-κB-mediated cellular FLICE-inhibitory protein

A new perspective of triptolide-associated hepatotoxicity: the relevance of NF-κB and NF-κB-mediated cellular FLICE-inhibitory protein

Previously, we proposed a new perspective of triptolide (TP)-associated hepatotoxicity: liver hypersensitivity upon lipopolysaccharide (LPS) stimulation. However, the mechanisms for TP/LPS-induced hepatotoxicity remained elusive. The present study aimed to clarify the role of LPS in TP/LPS-induced h...

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Bibliographic Details
Main Authors: Ziqiao Yuan, Zihang Yuan, Muhammad Hasnat, Haoran Zhang, Peishi Liang, Lixin Sun, Zhenzhou Jiang, Luyong Zhang
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Triptolide
LPS
TNF-α
NF-κB
FLIP
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383519307221

Internet

http://www.sciencedirect.com/science/article/pii/S2211383519307221

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