Thymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus-Prone Mice

Thymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus-Prone Mice

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the activation of autoreactive T and B cells, autoantibody production, and immune complex deposition in various organs. Previous evidence showed abnormal accumulation of B cells in the thymus of lupus-prone mice, but the ro...

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Bibliographic Details
Main Authors: Yessia Hidalgo, Sarah Núñez, Maria Jose Fuenzalida, Felipe Flores-Santibáñez, Pablo J. Sáez, Jessica Dorner, Ana-Maria Lennon-Dumenil, Victor Martínez, Emmanuel Zorn, Mario Rosemblatt, Daniela Sauma, Maria Rosa Bono
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
thymic B cells
germinal center
plasma cells
follicular helper T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00696/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00696/full

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