Increased EphA4-ephexin1 signaling in the medial prefrontal cortex plays a role in depression-like phenotype

Increased EphA4-ephexin1 signaling in the medial prefrontal cortex plays a role in depression-like phenotype

Abstract Accumulating evidence suggests a role of the ephrin receptor EphA4 and the downstream protein ephexin1 in synaptic plasticity, which is implicated in depression. We examined whether EphA4–ephexin1 signaling plays a role in the pathophysiology of depression, and the antidepressant-like effec...

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Bibliographic Details
Main Authors: Ji-chun Zhang, Wei Yao, Youge Qu, Mayumi Nakamura, Chao Dong, Chun Yang, Qian Ren, Min Ma, Mei Han, Yukihiko Shirayama, Akiko Hayashi-Takagi, Kenji Hashimoto
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-07325-2

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https://doi.org/10.1038/s41598-017-07325-2

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