The brains of aged mice are characterized by altered tissue diffusion properties and cerebral microbleeds

The brains of aged mice are characterized by altered tissue diffusion properties and cerebral microbleeds

Abstract Background Brain aging is a major risk factor in the progression of cognitive diseases including Alzheimer’s disease (AD) and vascular dementia. We investigated a mouse model of brain aging up to 24 months old (mo). Methods A high field (11.7T) MRI protocol was developed to characterize spe...

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Bibliographic Details
Main Authors: Erik N. Taylor, Nasi Huang, Jonathan Wisco, Yandan Wang, Kathleen G. Morgan, James A. Hamilton
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Translational Medicine
Subjects:
Brain imaging
Aging
Cerebral microbleeds (CMBs)
Vascular contributions to cognitive impairment and dementia (VCID)
Gradient-recalled echo MRI, diffusion tensor imaging
Online Access:http://link.springer.com/article/10.1186/s12967-020-02441-6

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http://link.springer.com/article/10.1186/s12967-020-02441-6

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