Brucella abortus Infection Elicited Hepatic Stellate Cell-Mediated Fibrosis Through Inflammasome-Dependent IL-1β Production

Brucella abortus Infection Elicited Hepatic Stellate Cell-Mediated Fibrosis Through Inflammasome-Dependent IL-1β Production

In human brucellosis, the liver is frequently affected. Brucella abortus triggers a profibrotic response on hepatic stellate cells (HSCs) characterized by inhibition of MMP-9 with concomitant collagen deposition and TGF-β1 secretion through type 4 secretion system (T4SS). Taking into account that it...

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Bibliographic Details
Main Authors: Paula Constanza Arriola Benitez, Ayelén Ivana Pesce Viglietti, Marco Tulio R. Gomes, Sergio Costa Oliveira, Jorge Fabián Quarleri, Guillermo Hernán Giambartolomei, María Victoria Delpino
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
Brucella
inflammasome
fibrosis
hepatic stellate cells
IL-1β
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03036/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03036/full

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