Obligatory Role of Intraluminal O2− in Acute Endothelin-1 and Angiotensin II Signaling to Mediate Endothelial Dysfunction and MAPK Activation in Guinea-Pig Hearts

Obligatory Role of Intraluminal O2− in Acute Endothelin-1 and Angiotensin II Signaling to Mediate Endothelial Dysfunction and MAPK Activation in Guinea-Pig Hearts

We hypothesized that, due to a cross-talk between cytoplasmic O2−-sources and intraluminally expressed xanthine oxidase (XO), intraluminal O2− is instrumental in mediating intraluminal (endothelial dysfunction) and cytosolic (p38 and ERK1/2 MAPKs phosphorylation) manifestations of vascular oxidativ...

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Bibliographic Details
Main Authors: Emilia Wojtera, Anna Konior, Natalia Fedoryszak-Kuśka, Andrzej Beręsewicz
Format: Article
Language:English
Published: MDPI AG 2014-10-01
Series:International Journal of Molecular Sciences
Subjects:
oxidative stress
endothelin-1
angiotensin-II
endothelial dysfunction
mitogen-activated protein kinases
mitochondria
NADPH-oxidase
xanthine oxidase
guinea-pig heart
Online Access:http://www.mdpi.com/1422-0067/15/11/19417

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http://www.mdpi.com/1422-0067/15/11/19417

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