Proteolysis of virulence regulator ToxR is associated with entry of Vibrio cholerae into a dormant state.

Vibrio cholerae O1 is a natural inhabitant of aquatic environments and causes the diarrheal disease, cholera. Two of its primary virulence regulators, TcpP and ToxR, are localized in the inner membrane. TcpP is encoded on the Vibrio Pathogenicity Island (VPI), a horizontally acquired mobile genetic...

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Bibliographic Details
Main Authors: Salvador Almagro-Moreno, Tae K Kim, Karen Skorupski, Ronald K Taylor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-04-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4388833?pdf=render