Ca2+-based allosteric switches and shape shifting in RGLG1 VWA domain

Ca2+-based allosteric switches and shape shifting in RGLG1 VWA domain

RGLG1 is an E3 ubiquitin ligase in Arabidopsis thaliana that participates in ABA signaling and regulates apical dominance. Here, we present crystal structures of RGLG1 VWA domain, revealing two novel calcium ions binding sites (NCBS1 and NCBS2). Furthermore, the structures with guided mutagenesis in...

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Bibliographic Details
Main Authors: Qin Wang, YaYu Chen, ShengPing Li, WenDi Yang, LiFang Sun, MeiQin Jang, XiuLing Wu, QianChao Wang, Lifei Chen, YunKun Wu
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
VWA domain
Open state
Closed state
Calcium ions binding site
Conformational change
Molecular dynamics simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037019304349

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http://www.sciencedirect.com/science/article/pii/S2001037019304349

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