Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis

Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis

Hepatocellular carcinoma (HCC) is one of the paramount causes of cancer-related death worldwide. Despite recent advances have been made in clinical treatments of HCC, the general prognosis of patients remains poor. Therefore, it is imperative to develop a less toxic and more effective therapeutic st...

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Bibliographic Details
Main Authors: Xueying Ren, Yanchun Li, Yi Zhou, Wanye Hu, Chen Yang, Qiangan Jing, Chaoting Zhou, Xu Wang, Jiayu Hu, Luyang Wang, Jing Yang, Hairui Wang, Haifeng Xu, Huanjuan Li, Xiangmin Tong, Ying Wang, Jing Du
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Redox Biology
Subjects:
Ferroptosis
Disulfiram
Hepatocellular carcinoma
Oxidative stress
Sorafenib
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721002810

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http://www.sciencedirect.com/science/article/pii/S2213231721002810

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