Formation of an RNA Quadruplex-Duplex Hybrid in Living Cells Between mRNA of the Epidermal Growth Factor Receptor (EGFR) and a G-Rich Antisense Oligoribonucleotide

Formation of an RNA Quadruplex-Duplex Hybrid in Living Cells Between mRNA of the Epidermal Growth Factor Receptor (EGFR) and a G-Rich Antisense Oligoribonucleotide

Antisense DNA oligonucleotides, short interfering RNAs (siRNAs), and CRISPR/Cas9 genetic tools are the most useful therapeutic nucleic acids regulating gene expression based on the antisense specificity towards messenger RNA. Here, we present an effective novel strategy for inhibiting translation ba...

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Bibliographic Details
Main Authors: Dorota Gudanis, Damian Kaniowski, Katarzyna Kulik, Daniel Baranowski, Zofia Gdaniec, Barbara Nawrot
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
G-quadruplex
quadruplex-duplex hybrid
RNA G-rich antisense oligonucleotide
EGFR mRNA
selective G4 fluorescent probe
oBMVC derivative
Online Access:https://www.mdpi.com/2073-4409/9/11/2375

Internet

https://www.mdpi.com/2073-4409/9/11/2375

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