Valproic Acid as a Potential Inhibitor of Plasmodium falciparum Histone Deacetylase 1 (PfHDAC1): An in Silico Approach

Valproic Acid as a Potential Inhibitor of Plasmodium falciparum Histone Deacetylase 1 (PfHDAC1): An in Silico Approach

A new Plasmodium falciparum histone deacetylase1 (PfHDAC1) homology model was built based on the highest sequence identity available template human histone deacetylase 2 structure. The generated model was carefully evaluated for stereochemical accuracy, folding correctness and overall structure qual...

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Bibliographic Details
Main Authors: Mohamed A. Abdallah Elbadawi, Mohamed Khalid Alhaj Awadalla, Muzamil Mahdi Abdel Hamid, Magdi Awadalla Mohamed, Talal Ahmed Awad
Format: Article
Language:English
Published: MDPI AG 2015-02-01
Series:International Journal of Molecular Sciences
Subjects:
PfHDAC1
malaria
valproic acid
histone deacetylase inhibitor, homology model
docking
molecular dynamics
binding energy
Online Access:http://www.mdpi.com/1422-0067/16/2/3915

Internet

http://www.mdpi.com/1422-0067/16/2/3915

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