IL-21 Induces an Imbalance of Th17/Treg Cells in Moderate-to-Severe Plaque Psoriasis Patients

IL-21 Induces an Imbalance of Th17/Treg Cells in Moderate-to-Severe Plaque Psoriasis Patients

Background: Psoriasis is a chronic immune-mediated inflammatory skin disease, with over-activated interleukin (IL)-17-producing CD4+ T cells (Th17) and repressed regulatory T (Treg) cells. IL-21 is a Th17-related cytokine and plays an important role in the pathogenesis of psoriasis. However, the mec...

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Bibliographic Details
Main Authors: Yuling Shi, Zeyu Chen, Zihan Zhao, Yingyuan Yu, Huayu Fan, Xiaoguang Xu, Xiaolin Bu, Jun Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
psoriasis
Th17 cells
Treg cells
IL-17A
IL-21
IL-22
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01865/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01865/full

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