Targeted Expression of TGFBIp Peptides in Mouse and Human Tissue by MALDI-Mass Spectrometry Imaging

Targeted Expression of TGFBIp Peptides in Mouse and Human Tissue by MALDI-Mass Spectrometry Imaging

Stromal corneal dystrophies are a group of hereditary disorders caused by mutations in the <i>TGFBI</i> gene. The mutant TGFBIp is prone to protein aggregation and the mutant protein gets deposited in the cornea, leading to severe visual impairment. The mutations lead to a corneal specif...

Full description

Bibliographic Details
Main Authors: Venkatraman Anandalakshmi, Guillaume Hochart, David Bonnel, Jonathan Stauber, Shigeto Shimmura, Rajamani Lakshminarayanan, Konstantin Pervushin, Jodhbir S. Mehta
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Separations
Subjects:
amyloid fibrils
cornea
lattice corneal dystrophy
matrix-assisted laser desorption ionization (MALDI)
mass spectrometry imaging (MSI)
TGFBIp
Online Access:https://www.mdpi.com/2297-8739/8/7/97

Internet

https://www.mdpi.com/2297-8739/8/7/97

Similar Items